CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. The company’s CRISPR/Cas9 is a revolutionary technology for gene editing which is the process of precisely altering specific sequences of genomic DNA. It has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, CAR T cell therapies, in vivo, and type 1 diabetes, as well as develops investigational CAR T programs, including an autologous, gene-edited CAR T program targeting glypican-3 (GPC3) for the potential treatment of solid tumors. The company’s lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease (SCD), and hemoglobinopathies in which a patient’s hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting cluster of differentiation 19 (CD19) and CTX131 targeting CD70 for oncology and autoimmune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and CTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated, Nkarta, Inc., and Capsida Biotherapeutics. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.
Pioneering Gene Therapy | CRISPR Therapeutics leads with Casgevy, a groundbreaking treatment for sickle cell disease and β-thalassemia, marking a new era in genetic medicine |
Pipeline Potential | Explore CRISPR's diverse clinical programs, including promising CAR-T therapies for cancer and autoimmune diseases, showcasing the platform's versatility |
Financial Health | With $1.9 billion in cash and analyst price targets ranging from $53 to $105, CRISPR balances strong liquidity against the costs of innovation |
Market Challenges | Delve into CRISPR's strategy to navigate a competitive landscape, regulatory hurdles, and the complexities of commercializing cutting-edge gene therapies |
Metrics to compare | CRSP | Sector Sector - Average of metrics from a broad group of related Healthcare sector companies | Relationship RelationshipCRSPPeersSector | |
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P/E Ratio | −9.8x | −1.6x | −0.5x | |
PEG Ratio | 0.15 | 0.01 | 0.00 | |
Price/Book | 2.1x | 1.1x | 2.6x | |
Price / LTM Sales | 100.5x | 4.1x | 3.1x | |
Upside (Analyst Target) | 93.8% | 118.0% | 48.3% | |
Fair Value Upside | Unlock | 5.5% | 7.6% | Unlock |