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Erasca, Inc., a clinical-stage precision oncology company, focuses on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. The company’s lead product is naporafenib which is in phase 1b trial for patients with RAS Q16X solid tumors and plans to initiate a pivotal Phase 3 trial for patients with NRASm melanoma. It also develops ERAS-007, an oral inhibitor of ERK1/2 for the treatment of non-small cell lung and colorectal cancer, and advanced gastrointestinal malignancies; and ERAS-601, an oral SHP2 inhibitor for patients with advanced or metastatic solid tumors. In addition, it is developing ERAS-801, a central nervous system-penetrant EGFR inhibitor which is in phase 1 clinical trials for the treatment of patients with recurrent glioblastoma multiforme. The company entered into license agreement with Novartis to develop, manufacture, use, and commercialize naporafenib; Katmai Pharmaceuticals, Inc. to develop, manufacture, use, and commercialize ERAS-801 and certain other related compounds; and NiKang Therapeutics, Inc. to develop and commercialize ERAS-601 and certain other related compounds. Erasca, Inc. was incorporated in 2018 and is headquartered in San Diego, California.
Name | Age | Since | Title |
---|---|---|---|
Pratik S. Multani | 57 | 2018 | Independent Director |
Valerie Harding-Start | 64 | 2019 | Independent Director |
James A. Bristol | 77 | 2018 | Independent Director |
John Lo | - | 2022 | Senior Commercial Advisor & Member of Research, Development and Commercial Advisory Board |
Alexander Whitman Casdin | 56 | 2018 | Independent Director |
Julie Hambleton | 66 | 2021 | Independent Director |
Karen Cichowski | - | - | Scientific Advisory Board Member |
Pablo Rodriguez-Viciana | - | - | Scientific Advisory Board Member |
Bruce D. Roth | - | - | Member of R&D Advisory Board |
Linda Robertson | - | - | Member of R&D Advisory Board |
Kevan M. Shokat | - | - | Scientific Advisory Board Member |
Jonathan E. Lim | 52 | 2018 | Co-Founder, Chairman & CEO |
Gregory Cosma | - | - | Member of R&D Advisory Board |
David Matthews | 81 | - | Member of R&D Advisory Board |
Paul G. Pearson | 63 | - | Member of R&D Advisory Board |
James L. Freddo | 69 | - | Member of R&D Advisory Board |
Ryan B. Corcoran | - | - | Scientific Advisory Board Member |
George Daniel Demetri | 67 | - | Scientific Advisory Board Member |
Stephen C. Blacklow | - | - | Scientific Advisory Board Member |
Jane Chang | - | - | Member of R&D Advisory Board |
Jean I. Liu | 56 | 2022 | Independent Director |
Michael D. Varney | 66 | 2020 | Chairman of Research & Development, Scientific Advisory Board Member and Director |
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