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ORIC Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, engages in the discovery and development of therapies for treatment of cancers in the United States. Its clinical stage product candidates include ORIC-114, a brain penetrant orally bioavailable irreversible inhibitor, currently under Phase 1b study, which is designed to selectively target epidermal growth factor receptor and human epidermal growth factor receptor 2 with high potency towards exon 20 insertion mutations; ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 for prostate cancer, currently under Phase 1b study; and ORIC-533, an orally bioavailable small molecule inhibitor of CD73, currently under Phase 1b study, being developed for resistance to chemotherapy- and immunotherapy-based treatment regimens. The company is also developing multiple discovery stage precision medicines targeting other cancer resistance mechanisms, including ORIC-613, an orally bioavailable, highly selective inhibitor of PLK4, in preclinical studies for the treatment of breast cancers. It has a license and collaboration agreement with Voronoi Inc.; a license agreement with Mirati Therapeutics, Inc.; and clinical development collaboration agreement with Pfizer Inc. The company was incorporated in 2014 and is headquartered in South San Francisco, California.
Name | Age | Since | Title |
---|---|---|---|
Peter H. E. Svennilson | 59 | 2014 | Independent Director |
Laurence A. Lasky | 70 | 2015 | Member of Scientific Advisory Board |
Mardi C. Dier | 57 | 2020 | Independent Director |
Lori Anne Kunkel | 63 | 2020 | Independent Director |
Charles L. Sawyers | 63 | - | Co-Founder & Member of Scientific Advisory Board |
Jacob M. Chacko | 43 | 2018 | President, CEO & Director |
Scott W. Lowe | - | - | Co-Founder & Member of Scientific Advisory Board |
Richard A. Heyman | 65 | 2015 | Co-Founder, Independent Chairman & Member of Scientific Advisory Board |
Angie J. You | 49 | 2021 | Independent Director |
Steven L. Hoerter | 51 | 2021 | Indepdnent Director |
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