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AstraZeneca discontinues phase III trials

Published Dec 01, 2023 08:00 Updated Dec 01, 2023 08:10
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© Reuters. AstraZeneca discontinues phase III trials
 
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Proactive Investors - AstraZeneca PLC (LON:AZN) has announced the discontinuation of two phase III trials, STABILIZE-CKD and DIALIZE-Outcomes, for its drug Lokelma (sodium zirconium cyclosilicate).

This decision stems from logistical challenges, including extended timelines for patient enrolment and lower-than-expected occurrences of the conditions being studied.

These trials were integral to the CRYSTALIZE evidence programme, aimed at exploring the effectiveness of Lokelma in treating hyperkalaemia (HK) across various heart and kidney conditions. Hyperkalaemia refers to a higher-than-normal level of potassium in the blood, which can be detrimental to cardiac and renal health.

AstraZeneca (NASDAQ:AZN) said the discontinuation is not linked to any safety concerns regarding Lokelma. The drug is currently approved in 56 countries for treating a broad spectrum of patients with hyperkalaemia. The company's decision does not affect the existing positive benefit-risk assessment of Lokelma for its approved use.

Read more on Proactive Investors UK

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AstraZeneca discontinues phase III trials
 

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Comments (1)
Dirk Reynen
Dirk Reynen Dec 01, 2023 8:47
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Discontinued after killing millions of people in trial i/ii and making billions profit the scandal is deep
He Wa
He Wa Dec 01, 2023 8:47
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did you read the article?
Abraham Iwakun
Abraham Iwakun Dec 01, 2023 8:47
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Why you say so?
 
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