Nuformix delighted as NXP004 testing exceeds the company’s expectations By Proactive Investors

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Nuformix delighted as NXP004 testing exceeds the company’s expectations

Published Dec 20, 2022 08:31 Updated Dec 20, 2022 08:40

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Nuformix delighted as NXP004 testing exceeds the company’s expectations

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Proactive Investors - Nuformix PLC has updated investors on its NXP004 programme which is developing novel forms of AstraZeneca’s Olaparib (Lynparza®) cancer drug.

Lynparza generated US$2.7bn of sales in 2021 though has presented challenges historically in terms of "pill burden" and low olaprib bioavailability, the company noted, and, it has so far filed two patent applications covering novel forms of olaparib with the potential of protection out to 2041.

These novel forms of Olaparib have undergone tests which have shown enhanced dissolution of the drug, compared to dissolution, and the company today highlighted these positive results.

"I'm delighted with the results of the head-to-head dissolution studies, which exceeded my expectations and have demonstrated first-time that the lead NXP004 cocrystals offer significant scope for enhanced performance versus Lynparza®, for which biorelevant dissolution data is not in the public domain,” said executive director Dr Dan Gooding.

“The NXP004 cocrystals studied demonstrate some of the best dissolution performance I've seen from application of the technology - a step-change in dissolution performance, yet they appear to lack any of the common drawbacks that can hamper development of cocrystal-based products, which is surprising.

“These new data strongly support progression of the programme and we will now look to translate these enhancements into an in-vivo setting, which if successful will position the company well for commencing partnering discussions with multiple potential partners identified."

Nuformix told investors it will now look at the design of suitable pre-clinical pharmacokinetic models to further investigate and validate NXP004's potential for enhancing the oral absorption of Olaparib, ahead of the commencement of talks with multiple potential commercialisation partners.

Read more on Proactive Investors UK

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