CAMBRIDGE, Mass. - Immuneering Corporation (NASDAQ:IMRX), a biotechnology firm specializing in oncology, has shared preclinical data at the American Association for Cancer Research (AACR) Annual Meeting, indicating that its drug IMM-1-104 may enhance the efficacy of standard chemotherapies for pancreatic cancer.
The data suggest that when IMM-1-104 is combined with chemotherapies used in first-line pancreatic cancer treatment, it results in more profound and lasting tumor growth inhibition than either treatment alone.
This information comes on the heels of the company's recent Phase 1 trial results and is seen as supportive of Immuneering's ongoing Phase 2a clinical trial of IMM-1-104, which targets RAS-mutated advanced or metastatic solid tumors. IMM-1-104 is currently being evaluated as a monotherapy and in combination with approved chemotherapeutic agents.
According to Brett Hall, Ph.D., Chief Scientific Officer at Immuneering, the preclinical findings demonstrate IMM-1-104's potential when used in conjunction with chemotherapy. The data presented showed that IMM-1-104, in combination with chemotherapeutic agents such as gemcitabine, nab-paclitaxel, and fluorouracil, led to synergistic effects in animal models of pancreatic cancer.
In the Phase 2a trial, multiple patients with pancreatic cancer are now receiving IMM-1-104 in combination with chemotherapy in a first-line setting.
The Phase 2a portion of the trial includes five arms, three of which are focused on patients with pancreatic cancer. Immuneering anticipates initial data from these trials to become available in 2024.
Immuneering is committed to developing universal-RAS/RAF medicines that could benefit a broad population of cancer patients. The company's lead product candidate, IMM-1-104, is part of a broader development pipeline that includes several early-stage programs.
The company's approach involves Deep Cyclic Inhibition of the MAPK pathway, which is designed to impact cancer cells while sparing healthy cells. This strategy is aimed at addressing therapeutic resistance, a common challenge in cancer treatment.
The information shared in this article is based on a press release statement.
InvestingPro Insights
As Immuneering Corporation (NASDAQ:IMRX) showcases promising preclinical data for its oncology drug, IMM-1-104, investors and stakeholders are closely monitoring the company's financial health and market performance.
Immuneering's commitment to advancing cancer treatment through its RAS/RAF medicines is mirrored by a notable financial metric: despite recent challenges, the company holds more cash than debt on its balance sheet, which could provide a cushion as it continues to fund its clinical trials and research endeavors.
From a market perspective, the stock has experienced significant volatility. The price has seen a considerable decline over the last year, with the one-year price total return standing at -78.32%, reflecting a price that is currently only 14.84% of its 52-week high. This volatility is a critical factor for investors to consider, especially those looking for potential entry points into the market or assessing the stock's risk profile.
An InvestingPro Tip suggests that Immuneering's stock is currently in oversold territory based on the Relative Strength Index (RSI), which may interest traders looking for potential rebounds. However, it's essential to note that the company is quickly burning through cash, a situation that investors must weigh against the potential of IMM-1-104 and the broader pipeline of products.
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