Sharecast - Online supermarket Ocado (LON:OCDO) slid, having rocketed on Thursday amid speculation it could be takeover target for Amazon (NASDAQ:AMZN).
Housebuilders Persimmon (LON:PSN), Berkeley, Taylor Wimpey (LON:TW) and Barratt all fell amid concerns about the impact of surging borrowing costs.
GSK (LON:GSK) rallied after the pharmaceuticals group said that a Zantac trial that was due to begin next month in California was dismissed after a confidential settlement was agreed.
Danni Hewson, head of financial analysis at AJ Bell, said: "News pharmaceutical giant GSK has settled a case in California alleging its Zantac heartburn medication caused cancer, while crucially admitting no liability, is not a full stop on the saga but is the latest punctuation point in what shareholders will hope is its final stanza.
"Once the world’s best-selling drug, there have been a series of lawsuits brought in the US implying a link between Zantac and cancer but, so far, GSK has been able to navigate its way through these choppy waters. A court ruling in Florida before Christmas, which provided a comprehensive dismissal of the plaintiffs’ arguments, proved a bit of a lode star for the company.
"As it begins to put this issue behind it, focus will turn to its efforts to catch up with its close UK peer AstraZeneca (NASDAQ:AZN) which has drastically outperformed it in share price terms in recent years."
FTSE 100 - Risers
GSK (GSK) 1,420.20p 4.50%
Convatec Group (CTEC (LON:CTEC)) 211.80p 2.42%
Croda International (CRDA) 5,566.00p 2.09%
British American Tobacco (LON:BATS) 2,620.00p 1.18%
Pearson (LON:PSON) 820.40p 1.16%
Associated British Foods (LON:ABF) 1,955.50p 0.98%
Vodafone Group (LON:VOD) 72.57p 0.93%
Halma (LON:HLMA) 2,252.00p 0.72%
Severn Trent (LON:SVT) 2,707.00p 0.71%
National Grid (LON:NG.) 1,042.50p 0.63%
FTSE 100 - Fallers
Ocado Group (OCDO) 526.00p -7.36%
JD Sports Fashion (JD.) 141.95p -5.21%
International Consolidated Airlines Group (LON:ICAG) SA (CDI) (IAG) 159.65p -3.74%
Smith (DS) (SMDS) 270.10p -3.67%
Persimmon (PSN) 1,063.00p -3.67%
Anglo American (LON:AAL) 2,264.00p -2.87%
Glencore (LON:GLEN) 433.55p -2.79%
Berkeley Group Holdings (The) (BKG) 3,765.00p -2.76%
Taylor Wimpey (TW.) 100.00p -2.63%
Barratt Developments (LON:BDEV) 407.40p -2.61%