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Bicycle Therapeutics retains stock target, buy rating on upcoming data

EditorNatashya Angelica
Published 26/11/2024, 13:58
BCYC
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On Tuesday, Bicycle Therapeutics (NASDAQ:BCYC) sustained its Buy rating and $38.00 stock price target by Needham, following the anticipation of abstracts for Zelenectide Pevedotin's data, set to be presented at the San Antonio Breast Cancer Symposium on December 12, 2024. The data is expected to show encouraging early results for the monotherapy in patients with triple-negative breast cancer (TNBC) who have nectin-4 amplification.

Despite a decrease in the overall response rate (ORR) for all TNBC patients from approximately 20% as of September 27, 2023, to 13.3% by August 29, 2024, the ORR for patients with positive nectin-4 gene amplification, including those with polysomy, was reported at 57%.

The subset of seven patients showed a response rate that is seen as competitive when compared to Mabwell's ADC 9MW2821, which had a 50% ORR in a group of 20 patients, 93% of whom were nectin-4 positive.

The company is preparing to host an investor call on December 13th at 7 AM CT, where they plan to provide further updates on Zelenectide Pevedotin. The updates will include information on the drug's combination with pembro as a first-line treatment for metastatic urothelial carcinoma (mUC) and its use as a monotherapy for non-small cell lung cancer (NSCLC).

Bicycle Therapeutics' focus on Zelenectide Pevedotin and its potential in treating various forms of cancer has kept the investment firm's outlook positive. The upcoming symposium and investor call are expected to shed more light on the drug's efficacy and future prospects.

In other recent news, Bicycle Therapeutics has seen several significant developments. Leerink Partners raised Bicycle Therapeutics' target to $32, maintaining an Outperform rating based on the company's third-quarter financial results and pipeline progress.

The company also reported advancements in its Bicycle Toxin Conjugate (BTC) and Bicycle Radio Conjugate (BRC) franchises, with particularly supportive data from zelenectide pevedotin for the ongoing Duravelo-2 pivotal study.

Analyst firms H.C. Wainwright, Oppenheimer, and B.Riley have maintained their respective Buy, Outperform, and Neutral ratings, citing potential advancements in the BRC platform. The company has secured approximately $555 million through PIPE financing, extending its financial runway into the second half of 2027.

Further, Bicycle Therapeutics is expected to release more data updates in the second half of 2024. These will include information on zelenectide pevedotin in combination with pembrolizumab for first-line metastatic urothelial carcinoma treatment, as well as monotherapy in late-line triple-negative breast cancer and non-small cell lung cancer. These are the recent developments surrounding Bicycle Therapeutics.

InvestingPro Insights

Recent InvestingPro data provides additional context to Bicycle Therapeutics' (NASDAQ:BCYC) financial position and market performance. Despite the company's promising drug developments, it's important to note that BCYC is not currently profitable, with a negative P/E ratio of -8.33 over the last twelve months as of Q3 2024. This aligns with an InvestingPro Tip indicating that analysts do not anticipate the company to be profitable this year.

However, BCYC's financial health shows some positive signs. An InvestingPro Tip highlights that the company holds more cash than debt on its balance sheet, which could provide flexibility for ongoing research and development efforts. Moreover, BCYC's liquid assets exceed short-term obligations, suggesting a stable short-term financial position.

The stock's recent performance has been mixed. While BCYC has shown a strong return over the last five years, it has fared poorly over the last month, with a 1-month price total return of -19.33%. This recent dip might present an opportunity, as another InvestingPro Tip suggests the stock's RSI indicates it may be in oversold territory.

For investors seeking a more comprehensive analysis, InvestingPro offers 5 additional tips that could provide valuable insights into BCYC's investment potential.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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