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Adagene shares downgraded to hold, target cut to $3.50

Published 15/11/2024, 19:20
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On Friday, Adagene Inc (NASDAQ: ADAG) experienced a shift in stock rating as Jefferies lowered its recommendation from Buy to Hold. Accompanying this downgrade was a significant reduction in the price target, which was adjusted to $3.50 from the previous $8.00.

The adjustment in rating and price target follows observations of Adagene's ADG126, an anti-CTLA-4 therapy. While the treatment has displayed promising activities and safety profiles in past years, including recent presentations at STIC'24, its efficacy appears more pronounced in a specific patient subset. This subset excludes those with liver and peritoneal metastases.

Jefferies noted the selective patient population for ADG126 poses questions regarding the regulatory development pathway. This uncertainty has led to a revised projection for the commercial launch of the therapy, pushing the expected date from 2028 to 2029.

The analyst from Jefferies stated, "ADAG's ADG126 is an anti-CTLA-4 that has shown encouraging activities and safety over the past years, and more recently at STIC'24." However, they also highlighted the limited clarity on the drug's regulatory future, prompting a more cautious stance on the stock until more information becomes available.

In other recent news, Adagene Inc. has announced significant findings at the Society for Immunotherapy of Cancer (SITC) and the European Society of Medical (TASE:PMCN) Oncology (ESMO) Congress. The biopharmaceutical company presented research on its proprietary SAFEbody® technology platform, particularly the anti-CTLA-4 antibody, ADG126. These findings demonstrated the potential for enhanced safety and efficacy in cancer immunotherapy, with a focus on metastatic microsatellite stable colorectal cancer (MSS-CRC) treatment.

The combination of ADG126 with pembrolizumab showed a confirmed overall response rate of 24% and a disease control rate of 88% in recent studies. These developments underscore the company's commitment to developing innovative treatments that may improve patient outcomes.

Analysts from H.C. Wainwright have maintained a Buy rating on Adagene, reinforcing confidence in ADG126's potential. Despite recent stock value fluctuations, the analysts consider the stock undervalued given the promising results and the company's current market capitalization of approximately $100 million. These recent developments may offer a new avenue for MSS-CRC patients who typically have limited treatment options.

InvestingPro Insights

Recent InvestingPro data provides additional context to Adagene Inc's (NASDAQ: ADAG) current situation. The company's market capitalization stands at $99.61 million, reflecting its position as a niche player in the biotechnology industry. This aligns with the article's focus on the company's specific anti-CTLA-4 therapy, ADG126.

InvestingPro Tips highlight that Adagene is quickly burning through cash and is not expected to be profitable this year. This information adds depth to the analyst's cautious stance, as it underscores the financial challenges the company may face while developing its key therapy.

The stock's recent performance has been mixed. While it has seen a high return over the last year with a 70.59% price total return, it has also experienced a significant 12.12% drop in the past week. This volatility reflects the uncertainty surrounding ADG126's regulatory pathway, as mentioned in the article.

For investors seeking a more comprehensive analysis, InvestingPro offers 14 additional tips for Adagene Inc, providing a broader perspective on the company's financial health and market position.

This article was generated with the support of AI and reviewed by an editor. For more information see our T&C.

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